A Review on Novel Natural Polymers Used in Fast Dissolving Tablets
Keywords:
Chitosan, Fenugreek seed mucilage, Mango peel pectin, Pullulan, RosinAbstract
The oral route is often considered one of the most effective, convenient, and safe methods for drug administration. In recent years, Fast-Dissolving Tablets (FDTs) have gained popularity due to their ability to quickly dissolve in the mouth without the need for water. This innovation is especially helpful for individuals who have difficulty swallowing, including both elderly and pediatric patients. Natural polymers have emerged as preferred excipients in these formulations because they are abundant, cost-effective, non-toxic, biodegradable, and chemically stable. Unlike synthetic polymers, natural ones tend to be safer and are less likely to cause adverse effects. Studies have shown that they can improve the performance of drug formulations by acting as binders, fillers, and disintegrants. Additionally, they enlarge the solubility of poorly water-soluble drugs, downturn disintegration time, and support nutritional nutriment. This review focuses on the latest applications of natural polymers such as Rosin, Chitosan, and Pullulan in the development of fast-dissolving pellets.
References
Maskare RG, Indurwade NH, Yadav AO, Kesharwani AS, Jain AA, Bisen VK, Kotangale AT. Natural superdisintegrant: Opportunity in oral drug delivery system. Asian. J. Pharm. Tech. 2021; 11(2):135-40. https://doi.org/10.52711/2231-5713.2021.00022
Allen L, Ansel HC. Ansel's pharmaceutical dosage forms and drug delivery systems. Lippincott Williams & Wilkins; 2013.
Chaturvedi A, Srivastava P, Yadav S, Bansal M, Garg G, Kumar Sharma P. Fast dissolving films: a review. Current. Drug. Delivery. 2011; 8(4):373-80. https://doi.org/10.2174/156720111795768022
Kalyan S, Bansal M. Recent trends in the development of oral dissolving film. Int. J. Pharm. Tech. Res. 2012; 4(2):725-33. https://sphinxsai.com/2012/pharmaj/PHARM/PT=29%5B725-733%5DAJ12.pdf
Goel H, Tiwary AK, Rana V. Fabrication and optimization of fast disintegrating tablets employing interpolymeric chitosan-alginate complex and chitin as novel superdisintegrants. Acta. Pol. Pharm. 2011; 68(4):571-83. Available: https://pubmed.ncbi.nlm.nih.gov/21796940/
Lakshmi PK, Lavanya D, Ali MH. Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films. Int. Curr. Pharm. J. 2014; 3(3):243-6. https://doi.org/10.3329/icpj.v3i3.17892
Chauhan V, Kumar K, Teotia D. Fast dissolving tablets: a promising approach for drug delivery. Univ. J. Pharm. Res. 2017; 2(4):51-57. https://doi.org/10.22270/ujpr.v2i4.RW4
Alam MT, Parvez N, Sharma PK. FDA‐approved natural polymers for fast dissolving tablets. J. Pharm. 2014; 2014(1):952970. https://doi.org/10.1155/2014/952970
Singh R, Saxena S, Jain S. Formulation and evaluation of mouth dissolving tablet containing non-steroidal anti-inflammatory drug. Res. J. Pharm. Technol. 2021; 14(1):432-6. https://doi.org/10.5958/0974-360X.2021.00078.0
Kumar MU, Babu MK. Design and evaluation of fast dissolving tablets containing diclofenac sodium using fenugreek gum as a natural superdisintegrant. Asian. Pac. J. Trop. Biomed. 2014; 4: S329-34. https://doi.org/10.12980/apjtb.4.2014b672
11.Rajeswari S, Prasanthi T, Sudha N, Swain RP, Panda S, Goka V. Natural polymers: A recent review. World. J. Pharm. Pharm. Sci. 2017; 6(8):472-94. Available: https://wjpps.com/wjpps_controller/abstract_id/7480
Sunitha HS, Parthiban S, Vikneshwiri A, SenthilKumar GP, Tamiz Mani T. Development and evaluation of captopril fast disintegrating or dissolving tablets by complexation techniques using guar Gum as a superdisintegrant. Int. J. Res. Pharm. Nano Sci. 2015; 4(2):72-84.
Mohammed S, Sharma SK, Kaucha K, Hiremath D. Formulation and evaluation of flurbiprofen fast disintegrating tablets using natural superdisintegrants. Asian. J. Pharm. Clin. Res. 2016; 9(6):247-54. https://doi.org/10.22159/ajpcr.2016.v9i6.14303
Nagar M, Yadav AV. Cinnarizine orodispersible tablets: A chitosan based fast mouth dissolving technology. Int. J. Pharm. Tech. Res. 2009; 1(4):1079–91. Available: https://d1wqtxts1xzle7.cloudfront.net/31067868/pt_18_%281079-1091%29-libre.pdf?1392127110=&response-content disposition=inline%3b+filename%3dcinnarizine_orodispersible_tablets_a_chi.pdf&
Naqvi AA. Evolution of clinical pharmacy teaching practices in Pakistan. Arch. Pharm. Pract. 2016; 7(1):26-8. Available: https://archivepp.com/article/evolution-of-clinical-pharmacy-teaching-practices-in-pakistan
Shahtalebi MA, Tabbakhian M, Koosha S. Formulation and evaluation of orally disintegrating tablet of ondansetron using natural superdisintegrant. J Herbmed Pharmacol. 2015;4(3):102-9. Available: https://herbmedpharmacol.com/Article/JHP_20150714200002
Delgoda R. Pharmacognosy: Fundamentals, applications and strategies. Academic Press; 2016.
