Exploring the Botany of Bloodroot: Sanguinaria Canadensis

Authors

  • S. Kamali
  • K. Atchaya
  • S. Varsha
  • E. Hamsini Eisha
  • W. Helen

Keywords:

Bloodroot, Conservation, Dental Products, Medicinal herbs, Nontimber forest products, Sanguinaria

Abstract

Bloodroot [Sanguinaria canadensis] is a herbaceous perennial in the eastern United States that blooms in the mountains of Appalachia in the spring and grows mostly in dense woodlands. The colloquial term bloodroot and the scientific name Sanguinaria refer to the blood-red fluid found throughout the plant, particularly in its roots. The alkaloid that gives this plant its high value is present in the juice. Native Americans utilized bloodroot as medicine, color, and for love spells. European colonizers altered American indigenous peoples’ healing techniques to satisfy their specific needs. Bloodroots have been thoroughly explained since the nineteenth century, including pharmacophore components, medicinal applications, and case studies. As the pharmaceutical business expanded in the 1920s, the use of herbal remedies became more widespread. However, research has proven that certain traditional uses of herbal medicines are helpful, sparking renewed interest in herbal treatments. In the United States, bloodroot is still widely used for both domestic and international uses. This page describes the properties and development patterns of bloodroots. It includes several herbal uses, analyzes worldwide markets and commerce, assesses system conservation status, and identifies areas that require more study.

References

Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2020; 109:69–75. https://doi.org/10.2307/3434847

Vogel VJ. American Indian Medicine. Norman (OK): University of Oklahoma Press; 2023. https://www.oupress.com/9780806122939/american-indian-medicine/

Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res. 2020; 23:385–98. https://doi.org/10.1002/ptr.2636

Damm DD, Fantasia JE. White patch of maxillary vestibule. Sanguinarine-associated leukoplakia. General dentistry. 2002 Sep 1;50(5):466-468. https://pubmed.ncbi.nlm.nih.gov/12448901/

Lu JJ, Bao JL, Chen XP, Huang M, Wang YT. Alkaloids isolated from natural herbs as the anticancer agents. Evidence‐Based Complementary and Alternative Medicine. 2012;2012(1):485042. https://doi.org/10.1155/2012/485042

Miao F, Yang XJ, Zhou L, Hu HJ, Zheng F, Ding XD, et al. Structural modification of sanguinarine and chelerythrine and their antibacterial activity. Nat Prod Res. 2021; 25:863–75. https://doi.org/10.1155/2012/485042

Shu D, Zhu Y, Lu M, He AD, Chen JB, Ye DS, Liu Y, Zeng XB, Ma R, Ming ZY. Sanguinarine attenuates collagen-induced platelet activation and thrombus formation. Biomedicines. 2021 Apr 21;9(5):444. https://doi.org/10.3390/biomedicines9050444

Kosina P, Walterova D, Ulrichová J, Lichnovský V, Stiborová M, Rýdlová H, Vičar J, Krečman V, Brabec MJ, Šimánek V. Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment. Food and Chemical Toxicology. 2004 Jan 1;42(1):85-91. https://doi.org/10.1016/j.fct.2003.08.007

Jäggi R, Würgler U, Grandjean F, Weiser M. Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability. Inflammation Research. 2004 Mar; 53:150-7. https://doi.org/10.1007/s00011-003-1236-y

Hou JL, Brewer JD. Black salve and bloodroot extract in dermatologic conditions. Cutis. 2015 Jun 1;95(6):309-11. https://pubmed.ncbi.nlm.nih.gov/26125206/

Vlachojannis C, Magora F, Chrubasik S. Rise and fall of oral health products with Canadian bloodroot extract. Phytotherapy Research. 2012 Oct;26(10):1423-6.https://doi.org/10.1002/ptr.4606

Eastman KL, McFarland LV, Raugi GJ. A review of topical corrosive black salve. The Journal of Alternative and Complementary Medicine. 2014 Apr 1;20(4):284-9. https://doi.org/10.1089/acm.2012.0377

Laub DR. Death from metastatic basal cell carcinoma: herbal remedy or just unlucky? Journal of plastic, reconstructive & aesthetic surgery. 2008 Jul 1;61(7):846-8. https://www.jprasurg.com/article/S1748-6815(08)00219-2/abstract

Gaziano R, Moroni G, Buè C, Miele MT, Sinibaldi-Vallebona P, Pica F. Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives. World Journal of Gastrointestinal Oncology. 2016 Jan 15;8(1):30. https://www.wjgnet.com/1948-5204/full/v8/i1/30.htm

Schwartzberg L, Osswald SS, Elston DM. Botanical briefs: bloodroot (Sanguinaria canadensis). Cutis. 2021 Oct 1;108(4):212-14. https://pubmed.ncbi.nlm.nih.gov/34847001/

Fu C, Guan G, Wang H. The anticancer effect of sanguinarine: A review. Current Pharmaceutical Design. 2018 Jul 1;24(24):2760-4. https://doi.org/10.2174/1381612824666180829100601

Karp JM, Rodrigo KA, Pei P, Pavlick MD, Andersen JD, McTigue DJ, Fields HW, Mallery SR. Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues. Toxicology letters. 2005 Jul 28;158(1):50-60. https://doi.org/10.1016/j.toxlet.2005.02.007

Keith CT, Borisy AA, Stockwell BR. Multicomponent therapeutics for networked systems. Nature reviews Drug discovery. 2005 Jan 1;4(1):71-8. https://www.nature.com/articles/nrd1609

Krstin S, Peixoto HS, Wink M. Combinations of alkaloids affecting different molecular targets with the saponin digitonin can synergistically enhance trypanocidal activity against Trypanosoma brucei brucei. Antimicrobial agents and chemotherapy. 2015 Nov;59(11):7011-7. https://doi.org/10.1128/aac.01315-15

Kulp M, Bragina O. Capillary electrophoretic study of the synergistic biological effects of alkaloids from Chelidonium majus L. in normal and cancer cells. Analytical and bioanalytical chemistry. 2013 Apr;405(10):3391-7. https://pubmed.ncbi.nlm.nih.gov/23358674/

Maranda EL, Wang MX, Cortizo J, Hsieh S, Danek D, Jimenez JJ. Flower power the versatility of bloodroot. JAMA dermatology. 2016 Jul 1;152(7):824. https://pubmed.ncbi.nlm.nih.gov/27409050/

Setzer WN. The phytochemistry of Cherokee aromatic medicinal plants. Medicines. 2018 Nov 12;5(4):121. https://doi.org/10.3390/medicines5040121

Croaker A, King GJ, Pyne JH, Anoopkumar-Dukie S, Liu L. Sanguinaria canadensis: traditional medicine, phytochemical composition, biological activities and current uses. International journal of molecular sciences. 2016 Aug 27;17(9):1414. https://doi.org/10.3390/ijms17091414

Graf TN, Levine KE, Andrews ME, Perlmutter JM, Nielsen SJ, Davis JM, Wani MC, Oberlies NH. Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.). Journal of agricultural and food chemistry. 2007 Feb 21;55(4):1205-11. https://pubs.acs.org/doi/10.1021/jf062498f

Published

2025-04-19