International Journal of Phyto Pharmaceutics and Research

The Impact of AI on Advancing Anti-Addiction Therapeutics

V Saili — 2025-12-17

Substance use disorders affect a large portion of the global population and continue to create major health challenges and current therapeutic strategies remain insufficient to address their complex neurobiological support. Traditional drug discovery methods are slow, expensive, and often ineffective in identifying novel anti-addiction agents. Artificial Intelligence (AI) has emerged as a transformative tool, offering advanced computational techniques such as machine learning (ML), deep learning (DL), natural language processing (NLP), and neural network based predictive modelling.AI-driven approaches enable the integration of large-scale biological, chemical, and clinical datasets to uncover hidden patterns underlying addiction-related pathways. ML and DL models can analyze genomic, proteomic, and neuroimaging data to identify novel molecular targets involved in reward circuitry, craving, and relapse mechanisms. NLP techniques further assist by mining vast biomedical literature, clinical trial repositories, and electronic health records to extract relevant insights and accelerate hypothesis generation. Additionally, reinforcement learning and generative models facilitate de novo molecular design by proposing chemically valid and biologically relevant compounds with improved efficacy and safety profiles. AI-based ADMET prediction reduces late-stage failures by optimizing pharmacokinetic and toxicity parameters early in the discovery pipeline. Collectively, these computational strategies significantly reduce time, cost, and attrition rates compared to conventional approaches, while enabling more personalized and mechanism-driven therapeutic development for substance use disorders. This paper explores the mechanisms, methodologies, and outcomes associated with AI-driven anti-addiction drug discovery. Case studies, datasets, and model outputs are discussed to demonstrate practical applications and future potential.

Novel Pharmaceutical Dosage Forms of Gymnema Sylvestre and Fenugreek for Enhanced Antidiabetic Efficacy

Monika L — 2025-12-29

Diabetes mellitus is a habitual metabolic complaint characterized by elevated blood glucose levels due to insulin insufficiency or resistance, and requires effective and safe remedial interventions. Gymnema sylvestre and Fenugreek are two vastly studied medicinal plants with significant antidiabetic properties, attributed to their bioactive phytochemicals. Gymnema sylvestre contains gymnemic acids known for their capability to suppress sweet taste, stimulate insulin storage, regenerate pancreatic beta cells, and inhibit glucose absorption in the bowel. Fenugreek seeds are rich in saponins, filaments, and alkaloids that ameliorate insulin sensitivity, detention carbohydrate digestion, and reduce blood glucose and lipid levels. Traditional administration of these gravies faces challenges similar to poor bioavailability, insecurity of active composites, and variable remedial issues. To overcome these, recent medicinal exploration has concentrated on developing new capsule forms, including nanoparticles, nanoemulsions, liposomes, solid lipid nanoparticles, and repurposed extracts. These advanced delivery systems enhance the solubility and stability of gymnemic acids and fenugreek bioactives, promote sustained and targeted release, and ameliorate immersion and bioavailability. Preclinical and clinical studies support that these new phrasings give superior antidiabetic effects compared to crude extracts or conventional specifics. Nano-sized gymnemic acid phrasings have demonstrated enhanced hypoglycemic action by effectively inhibiting glucose absorption and stimulating insulin storage. Fenugreek nanoformulations amended with active saponins have shown better glycemic control, lipid profile normalization, and antioxidant benefits. Likewise, combined phrasings of Gymnema sylvestre and Fenugreek, occasionally integrated with reciprocal antidiabetic gravies, have displayed synergistic effects on glucose metabolism and associated diabetic complications. The new capsule forms also contribute to reduced dosing frequency, minimized side effects, and better case compliance, making them promising alternatives for integrative diabetes management. Continued innovative expression strategies and clinical substantiation are essential to completely harness the remedial eventuality of these gravies while ensuring safety and effectiveness.

Formulation and Evaluation of a Polyherbal Hair Oil Based on Ayurvedic Principles for Scalp and Hair Health

Akash Misal — 2025-12-29

Hair care is vital for both health and aesthetics, and Ayurveda traditionally advocates herbal oils to strengthen the scalp, prevent hair loss, and maintain hair vitality. Modern cosmetic science has revived these practices, combining them with scientific evaluation to create safe, effective, and sustainable products. This study aimed to develop and assess a polyherbal hair oil using coconut oil as the base, infused with onion, amla, fenugreek, hibiscus, curry leaves, aloe vera, ashwagandha, bhringraj, brahmi, and neem. Each herb was selected for its therapeutic properties, including antioxidant, antimicrobial, anti-dandruff, and follicle-stimulating effects. Coconut oil was chosen for its light molecular structure, deep penetration, and affinity for hair proteins. Herbs were infused through controlled heating, filtered, and stored in sterilized containers. The formulation targets multiple scalp and hair concerns, such as androgenic alopecia, dryness, premature greying, microbial infections, and hair shaft weakening, supporting the hair growth cycle (anagen, catagen, telogen) by nourishing follicles and improving scalp circulation. Evaluation included organoleptic and physicochemical testing. The oil exhibited a pleasant odor, greenish-yellow color, non-irritant nature, pH 6.5, density 0.96, sticky viscosity, solubility in non-polar solvents, acid value 3.14 mg KOH/g, and saponification value 7.29 mg KOH/g, indicating stability and safety. Individual herb contributions were evident: amla supplied antioxidants and vitamin C, fenugreek reduced hair fall, hibiscus prevented greying, aloe vera enhanced moisturization, bhringraj and brahmi stimulated follicles, neem acted as an antimicrobial, and onion strengthened roots. The study highlights the advantages of polyherbal oils over single-herb products through synergistic action, improving both therapeutic and cosmetic outcomes, including shine, smoothness, and manageability. As a natural, cost-effective, and biocompatible formulation, it addresses the limitations of synthetic hair products. The developed polyherbal hair oil shows potential as a safe, holistic, and sustainable solution for scalp and hair health, with further biological and clinical studies recommended to validate long-term efficacy.

The Multifaceted Role of Various Moringa Species in Nutrition: A Comprehensive Review

Shital A. Jadhav — 2025-12-29

Moringa is a rapidly growing plant that is prevalent globally, particularly thriving in humid, tropical, hot, and arid climates. It is renowned for its remarkable nutritional and therapeutic properties. It is an abundant source of antioxidants, anti-inflammatory substances, and immunomodulatory chemicals. It is recognized for its anti-diabetic attributes and its capacity to promote cardiovascular health. The plant contains beneficial fatty acids, including oleic and linoleic acids, as well as volatile compounds such as geijerene, linalool, and caryophyllene. Moreover, it contains abundant beneficial substances such as betasitosterol, stigmasterol, and campesterol. It supplies vital amino acids, such as arginine, leucine, glycine, and proline, making it a significant addition to a nutritious diet. Research suggests that Moringa may exhibit anticancer properties. Its leaves are rich in important vitamins and minerals. They are a rich source of vitamin C and B vitamins (B1, B2, B3), as well as calcium, potassium, iron, magnesium, amino acids, flavonoids, and glucosinolates.

A Review on Syzygium Alternifolium

Saikoteswar Sarma — 2025-12-29

Syzygium alternifolium is a tree species native to the region and is widely found across the Seshachalam Hill ranges of the southern Eastern Ghats, with a notable presence in the Tirumala Hills. Both the stem and fruits have been traditionally used for a long time in treating diabetes within indigenous medical systems. In addition, the fruits are commonly employed in the management of duodenal and gastric ulcers. Phytochemical investigations indicate that the plant contains a wide range of bioactive constituents, including flavonoids, tannins, terpenoids, and saponins, which are responsible for its antioxidant, antimicrobial, and anti-inflammatory activities. Furthermore, its fruits are consumed locally as food, providing essential nutrients and acting as a sustainable resource for rural communities. Ongoing research is focused on isolating and characterizing its active compounds to understand their therapeutic potential and possible applications in pharmaceuticals, offering prospects for developing novel natural remedies.