International Journal of Phyto Pharmaceutics and Research

Formulation and Evaluation of Murraya Koenigii Herbal Handwash

Thu, 26 Mar 2026 00:00:00 +0000

The growing awareness of the adverse effects associated with synthetic antimicrobial agents has led to increased interest in herbal-based personal care products. Herbal handwashes formulated using plant-derived bioactive compounds offer a safer, eco-friendly, and skin-compatible alternative to conventional chemical-based handwashes. Murraya koenigii (L.) Spreng, commonly known as curry leaf, is a medicinal plant belonging to the family Rutaceae and is widely used in traditional Indian medicine. This plant has gained significant scientific attention due to its broad-spectrum antimicrobial properties. Various parts of the plant, particularly the leaves, are rich in bioactive phytochemicals that contribute to its antimicrobial efficacy. Phyllanthus emblica L., commonly known as amla or Indian gooseberry, is an important medicinal plant. Amla is renowned for its rich phytochemical profile and wide range of pharmacological activities, making it a valuable ingredient in herbal cosmetic and personal care formulations, including herbal handwashes. Neem oil contributes additional antibacterial and antifungal action, xanthan gum acts as a natural thickening agent, and glycerine functions as a humectant. These results indicate the potential of herbal handwash formulations as effective, sustainable, and skin-friendly hygiene products.

Phytochemical Profiling and Evaluation of Anti-inflammatory, Antioxidant, Analgesic and Antidiarrheal Properties of Xanthosoma nigrum Leaves

Sat, 06 Jun 2026 00:00:00 +0000

Xanthosoma nigrum is a tropical rare plant species of Aracea family. This research work aimed to evaluate phytochemical screening and selected biological activities of the plant species. Crude ethanolic leaf extract was fractionated further by using n-hexane and chloroform. Phytochemical screening revealed that almost all extractives contained important chemical constituents, including alkaloids, glycosides, flavonoids, saponins, and reducing sugars. In DPPH free radical scavenging assay, the ethanol fraction showed strong inhibition of 69% at the highest concentration, 2000 µg/ml. The IC₅₀ value of the ethanol extract was 21.47 µg/ml, which also suggested the evidence of strong activity of the ethanol extract. In anti-inflammatory and membrane stabilization tests, the plant showed dose dependent gradual increase of activities. Among the three extracts, the ethanolic fraction demonstrated the greatest inhibition (83.19%) of acetic acid–induced writhing in experimental animals during the analgesic assay. The plant species also showed notable antidiarrheal effects in the castor oil–induced diarrhea model. Overall, these results indicate that this plant may serve as a promising source for discovering new drug candidate.

Unraveling the Link Between Oxidative Stress and Neurodegeneration: Therapeutic Approaches

Mehak, Arvinder Kaur, Anuja Chopra, Satvinder Kaur, Mansi — Wed, 25 Feb 2026 00:00:00 +0000

Oxidative-Stress (OS) is a state where the body’s antioxidant defenses are overwhelmed by Reactive O₂species, leading to cellular damage and potential harm to tissues. Numerous health problems, such as difficulties from diabetes mellitus, cancerous conditions, cardiac problems, and neurological/brain-related disorders, are associated with this phenomenon. Environmental factors, lifestyle choices, and dietary habits highly influence the excessive generation or formation of ROS. Symptoms usually emerge gradually as cells and tissues incur damage over time. Oxidative stress affects disease progression through mechanisms such as DNA injury, inflammation, mitochondrial impairment, and endothelial harm. Antioxidant substances, vitamin C and E, minerals, as well as phytochemicals, perform an important role in neutralising ROS through prevention, disruption, and inactivation processes. Despite certain methodological hurdles, biomarkers like malondialdehyde, isoprostanes, and 8-hydroxy-deoxyguanosine can be employed to evaluate oxidative stress. Dietary antioxidants, enzyme mimetics, and lifestyle changes are all effective approaches to mitigate oxidative stress. Understanding oxidative stress and strategies to manage it is crucial for creating treatments for chronic and degenerative diseases.