Design and Optimization of a Two-Stage Miller Compensated OTA for Cystic Fibrosis Diagnosis in 45 nm Technology Using Cadence
DOI:
https://doi.org/10.46610/RTSST.2025.v02i02.003Keywords:
Analog front-end (AFE), Cadence, Cystic fibrosis, Operational transconductance amplifier (OTA), StabilityAbstract
This work thoroughly investigates and analyses a two-stage Miller-compensated operational transconductance amplifier (OTA) that can be used in the analog front-end (AFE) block of the sensor interface circuit required for the sweat test analyzer to diagnose a life-threatening genetic disease named cystic fibrosis (CF). In doing so, the OTA has been designed and implemented using 45 nm process technology in the cadence simulation framework. Being an essential component in sensor interface circuits, the OTA has to achieve high gain, good transient and frequency response, as well as improved stability, and hence, its design has to meet several specs such as gain-bandwidth product (GBW), slew rate, phase margin, and power dissipation. However, due to increased short-channel effects, the design of OTA using 45 nm process technology is quite challenging. Therefore, a careful design process has been conducted to reduce these short-channel effects. Detailed AC, transient, and stability analyses have been performed along with tweaking the dimensions (channel length and width), the bias voltages and currents and the Miller-compensated capacitance ensures the optimization of the OTA demanded by its application in pre-amplification stages of the sweat-based CF diagnosis. The results obtained in cadence simulation runs for the proposed OTA show excellent promise to realize an AFE used for CF diagnosis with reduced chip size while maintaining accuracy and performance.
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