A Review on the Hepatoprotective Potential of Aloe Vera and Vitamin C against Diet-Induced Liver Damage: Role of Artificial Intelligence in Preclinical Research
Keywords:
Artificial Intelligence, Hepatoprotective, Liver diseases, Reactive oxygen speciesAbstract
Liver diseases, especially those brought on by unhealthy eating patterns, such as High-Fat, High-Fructose Diets (HFHFD), have grown to be a significant global health issue because of their close ties to obesity, Non-alcoholic fatty liver disease, and metabolic syndrome are related health conditions. The limitations imposed by conventional pharmacological treatments, including adverse effects and suboptimal efficacy, have increased interest in natural hepatoprotective agents. Aloe vera and Vitamin C are two promising compounds with potent antioxidant, anti-inflammatory, and hepatocyte-regenerative properties. Aloe vera, rich in polysaccharides and bioactive compounds, supports liver cell repair, reduces lipid peroxidation, and modulates inflammatory pathways. Vitamin C (ascorbic acid), abundantly found in Amla, neutralizes Reactive Oxygen Species (ROS), restores enzymatic antioxidants, and enhances collagen synthesis. This review highlights the synergistic hepatoprotective potential of Aloe vera and Vitamin C in mitigating diet-induced liver injury. In addition, recent advances in artificial intelligence (AI) provide novel tools to enhance the evaluation of such therapeutic agents. AI techniques, including machine learning, image analysis, and natural language processing, are revolutionizing preclinical research by optimizing experimental design, automating histopathology interpretation, and predicting treatment outcomes. This review emphasizes the integration of AI in hepatoprotective studies and advocates for further translational research on these natural agents for effective liver disease management.
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