In-Vitro Anticancer Activity of Camellia Sinensis (Green Tea) Leaves and Tabernaemontana Divaricata (Pinwheel Flower)

Elavarasi. E, J. Jayadurka, Ardhrasunil, Sudharsan. C, Karthik. S — Wed, 01 Apr 2026 00:00:00 +0000

Cancer is a major disease in humans and animals. It can be treated by several ways in modern technology. Some medicinal plants and herbal extracts mainly act on anticancer activity Camellia sinensis (tea leaves) and Tabernaemontana divaricata (pinwheel flower) both the plants mainly act on anticancer activity with proven cytotoxic properties. Tea leaves contain mainly polyphenols, such as catechins, while pinwheel flower contains mainly alkaloids. Both of the plant’s extracts collected and performed with preliminary phytochemical screening and it will be analysis by qualitative and quantitative methods with some instrumentation like ultra-visible spectrometer, Fourier transform infrared spectrometer, high performance liquid chromatography, gas chromatography mass-spectrometry. This extraction widely contain antioxidant, anti-inflammatory and anticancer activity. These extracts are currently used in pharmaceutical research and development. This study may help to identify phytochemical and evaluation of in-vitro cytotoxicity and drug discovery in future herbal anticancer formulations. This combination mainly increases the anticancer activity and very safe, cost effective, less toxicity for anticancer activity.

Pharmaceutical Co-crystals: A Tool to Enhance Drug Solubility and Bioavailability

Wed, 25 Mar 2026 00:00:00 +0000

Poor solubility of drugs remains a significant challenge in pharmaceutical development, leading to reduced bioavailability and compromised therapeutic efficacy. Pharmaceutical co-crystals have become a viable means of getting around these solubility restrictions and improving the bioavailability of medications that aren't very soluble. Co-crystals are multi-component crystalline structures made up of one or more coformers and an Active Pharmaceutical Ingredient (API) that are bound together by non-covalent bonds. Without changing the API's structure chemically, these interactions produce a distinct crystal lattice that modifies its physical characteristics. The review highlights the principles behind cocrystal formation, including the selection of suitable coformers based on hydrogen bonding, π-π stacking, and other intermolecular forces. Rational cocrystal design and screening techniques are discussed, emphasizing the applications of pharmaceutical co-crystals as a strategy for enhancing the bioavailability and solubility of drugs that are poorly soluble. Furthermore, the review explores various methods for cocrystal preparation and characterization techniques used to confirm cocrystal formation and assess the purity, stability, and performance of the Co-crystals. In conclusion, the potential of co-crystals as an innovative and versatile tool to enhance drug solubility and bioavailability, ultimately advancing the field of pharmaceutical sciences and improving patient treatment options.

Journal of Pharmacopoeia and Research

In-Vitro Anticancer Activity of Camellia Sinensis (Green Tea) Leaves and Tabernaemontana Divaricata (Pinwheel Flower)

Pharmaceutical Co-crystals: A Tool to Enhance Drug Solubility and Bioavailability