Formulation, Development, and Evaluation of a Novel Polyherbal Anti-Acne Roll-on Containing Nyctanthes arbor-tristis (Parijat) and Moringa oleifera Extracts

Abstract

Acne is a common long-term skin problem caused by bacteria called Cutibacterium acnes, excess oil production, and stress that can damage skin cells. Nowadays, many people prefer herbal treatments because they are gentle on the skin, have fewer side effects, and may also help against bacteria that do not respond well to regular medicines. In this study, a herbal anti-acne roll-on was prepared using Nyctanthes arbor-tristis (parijat) and Moringa oleifera. Parijat has antibacterial, anti-inflammatory, and antioxidant properties. The formulation was evaluated using properties like Phytochemical, antibacterial, and stability. Acne vulgaris affects a large portion of the population, particularly adolescents and young adults, and can have a significant impact on self-esteem and quality of life. Conventional treatments such as antibiotics and synthetic topical agents are often associated with side effects, including skin irritation, dryness, and the development of antimicrobial resistance. Therefore, the demand for safe and effective herbal alternatives has increased considerably. Moringa oleifera is a medicinal plant known for its rich content of bioactive compounds, including flavonoids, phenolics, and vitamins, which contribute to its antimicrobial and antioxidant activities. The combination of Nyctanthes arbor-tristis and Moringa oleifera may provide a synergistic effect in reducing acne-causing bacteria and inflammation while promoting healthy skin. The herbal roll-on formulation was developed for convenient application and better patient compliance. Various evaluation parameters were carried out to determine its quality, efficacy, and stability. The results indicated the presence of beneficial phytochemicals and demonstrated antibacterial activity against acne-causing microorganisms. Stability studies also confirmed that the formulation remained physically and chemically stable under different storage conditions, suggesting its potential as a natural and effective anti-acne treatment.