The Growing Impact of Diabetes on Global Tuberculosis Burden

Abstract

This review article delves into the intricate interplay between diabetes mellitus (DM) and tuberculosis (TB), two significant global health concerns. The study aims to comprehensively examine the relationship between these two conditions, considering their impact on susceptibility, severity, treatment outcomes, and public health implications. Diabetes mellitus significantly elevates the risk of contracting TB, making it a formidable comorbidity, especially in regions with a high burden of both diseases. The review underscores the importance of early detection of diabetes in TB patients to enhance disease control measures and highlights the need for improved diabetes screening and comprehensive chronic care. The study also discusses the potential role of host-directed therapies, such as metformin, in improving TB treatment outcomes in individuals with DM. It emphasizes the complexity of the interactions between these two conditions and the need for a comprehensive approach to address this challenging health comorbidity. Overall, this review article provides valuable insights into the intricate relationship between DM and TB, offering guidance for future research and healthcare strategies to better manage and mitigate the impact of this comorbidity on public health.