Formulation And Evaluation of Transdermal Patch by Using Tridax Procumbens, Neem Bark and Turmeric

Abstract

Transdermal patches are becoming an increasingly popular way to deliver medications because they release drugs slowly and steadily through the skin. By using bioactive compounds in a patch form, they offer a simple and non-invasive alternative to traditional oral or injectable treatments. This approach also helps avoid common issues like stomach irritation and the loss of drug potency that can occur during first-pass metabolism in the digestive system. The present study focuses on the formulation and evaluation of a polyherbal transdermal patch containing Tridax procumbens, Azadirachta indica (Neem) bark, and Curcumin for their combined anti-inflammatory, wound-healing, and antimicrobial activities. Essential elements such as permeation enhancers, polymers, and adhesives are vital for improving how well the drug moves through the skin and how effectively it is released from the patch. Ethanolic extracts of the selected plants were prepared and incorporated into a polymeric matrix composed of hydroxypropyl methyl cellulose (HPMC) and polyvinylpyrrolidone (PVP) using the solvent casting technique. Glycerol was used as a plasticizing agent to improve the patch’s flexibility and ability to stick to the skin. The findings indicate that the polyherbal transdermal patch offers an effective, controlled delivery system with a synergistic therapeutic effect, helping to manage inflammation, combat microbial infections, and support wound healing.