Convolutional Neural Network based Framework for Early Detection of Alzheimer’s Disease
Keywords:
Alzheimer’s Disease (AD), AD Neuroimaging Initiative (ADNI) Convolutional Neural Networks (CNNs), Deep Learning (DL), ImageAbstract
Alzheimer’s Disease (AD) is a degenerative brain disorder that leads to the slow decline of memory function over time, with no definitive cure currently available. Early detection is crucial for ensuring patients receive appropriate care. Numerous studies have utilized statistical and deep learning techniques to diagnose AD. Recently, deep learning techniques especially Convolutional Neural Networks (CNNs) have become increasingly popular for the early detection of Alzheimer’s disease. However, many existing CNN models, often employed through transfer learning, exhibit high computational complexity and large memory footprints. This project proposes an efficient CNN model for early AD detection, aiming to reduce computational complexity and memory footprint. The model is designed to predict AD across four categories: mild dementia, very mild dementia, non-dementia, and moderate dementia. The proposed model’s performance is compared against established pre-trained models to assess its efficiency in terms of classification accuracy and memory size. Specifically, our model achieves an accuracy of 98.77%, surpassing the accuracies of existing pre-trained models, including InceptionV3, VGG16, and ResNet50, by approximately 57.81%, 48.89%, and 48.74%, respectively. Also, the proposed model significantly reduced the memory requirements to 8.09MB when compared to InceptionV3 (83.17MB), VGG16 (56.13MB), and ResNet50 (89.98MB). This comparison shows the effectiveness of our proposed model in improving accuracy for early AD detection while addressing concerns regarding classification accuracy and memory usage.
References
A. Gamal, M. Elattar and S. Selim, “Automatic early diagnosis of Alzheimer’s disease using 3D deep ensemble approach,” in IEEE Access, vol. 10, pp. 115974-115987, 2022, doi: https://doi.org/10.1109/ACCESS.2022.3218621
M. Fabietti et al., “Early detection of Alzheimer’s Disease from cortical and hippocampal local field potentials using an ensembled machine learning model,” in IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 31, pp. 2839-2848, 2023, doi: https://doi.org/10.1109/TNSRE.2023.3288835
C. M. Chabib, L. J. Hadjileontiadis, and A. A. Shehhi, “DeepCurvMRI: Deep convolutional Curvelet transform-based MRI approach for early detection of Alzheimer’s Disease,” in IEEE Access, vol. 11, pp. 44650-44659, 2023, doi: https://doi.org/10.1109/ACCESS.2023.3272482
Q. Dao, M. A. El-Yacoubi and A. -S. Rigaud, “Detection of Alzheimer’s disease on online handwriting using 1D convolutional neural network,” in IEEE Access, vol. 11, pp. 2148-2155, 2023, doi: https://doi.org/10.1109/ACCESS.2022.3232396
S. Al-Shoukry, T. H. Rassem and N. M. Makbol, “Alzheimer’s diseases detection by using deep learning algorithms: A mini-review,” in IEEE Access, vol. 8, pp. 77131-77141, 2020, doi: https://doi.org/10.1109/ACCESS.2020.2989396
S. Ahmed et al., “Ensembles of patch-based classifiers for diagnosis of Alzheimer’s disease,” IEEE Access, vol. 7, pp. 73373–73383, 2019, doi: https://doi.org/10.1109/access.2019.2920011
M. M. S. Fareed et al., “ADD-Net: An effective deep learning model for early detection of Alzheimer’s disease in MRI scans,” IEEE Access, vol. 10, pp. 96930–96951, 2022, doi: https://doi.org/10.1109/access.2022.3204395
H. Guo and Y. Zhang, “Resting state fMRI and improved deep learning algorithm for earlier detection of Alzheimer’s disease,” IEEE Access, vol. 8, pp. 115383–115392, 2020, doi: https://doi.org/10.1109/access.2020.3003424
A. Shah, D. Lalakiya, S. Desai, Shreya, and V. Patel, “Early detection of Alzheimer’s disease using various machine learning techniques: A comparative study,” 2020 4th International Conference on Trends in Electronics and Informatics (ICOEI)(48184), Tirunelveli, India, 2020, pp. 522-526, doi: https://doi.org/10.1109/ICOEI48184.2020.9142975
N. Burgos, S. Bottani, J. Faouzi, E. Thibeau-Sutre, and O. Colliot, “Deep learning for brain disorders: from data processing to disease treatment,” Briefings in Bioinformatics, vol. 22, no. 2, pp. 1560–1576, Dec. 2020, doi: https://doi.org/10.1093/bib/bbaa310
F. U. R. Faisal and G. -R. Kwon, “Automated detection of Alzheimer’s disease and mild cognitive impairment using whole brain MRI,” in IEEE Access, vol. 10, pp. 65055-65066, 2022, doi: https://doi.org/10.1109/ACCESS.2022.3180073
S. Fathi, A. Ahmadi, Afsaneh Dehnad, Mostafa Almasi-Dooghaee, and Melika Sadegh, “A deep learning-based ensemble method for early diagnosis of Alzheimer’s disease using MRI images,” Neuroinformatics, Dec. 2023, doi: https://doi.org/10.1007/s12021-023-09646-2
A. R. Zouaoui, Y. Brik, B. Attallah, M. Djeriuoi, and M. Belkhelfa, “Transfer learning approach for Alzheimer’s disease diagnosis using MRI images,” 2022 International Conference of Advanced Technology in Electronic and Electrical Engineering (ICATEEE), M'sila, Algeria, 2022, pp. 1-6, doi: https://doi.org/10.1109/ICATEEE57445.2022.10093702
K. A. Shastry, V. Vijayakumar, M. K. M. V, M. B A, and C. B N, “Deep learning techniques for the effective prediction of Alzheimer’s disease: A comprehensive review,” Healthcare, vol. 10, no. 10, p. 1842, Sep. 2022, doi: https://doi.org/10.3390/healthcare10101842