Nanoemulgel: A Promising Process in Drug Delivery

Abstract

This represents one of the recently developed drug delivery systems, which merges the desirable properties of both nanoemulsions and hydrogels, thus aiming at offering a flexible and effective platform for therapeutic applications. Nanoemulsions are nanosized droplets dispersed in a continuous phase and can remarkably improve the solubility and bioavailability of poorly soluble drugs. However, hydrogels are three-dimensional polymer networks-meaning they can hold large amounts of water, hence controllable drug release and easier patient compliance. Combining the two technologies then provides an exciting solution to a number of challenges with respect to drug delivery presented by nanoemulgels.

The review focuses on the detailed formulation processes for obtaining stable nanoemulsions for nanoemulgel, including high-energy techniques, ultrasonication, and low-energy techniques, like phase inversion. In addition, the review encompasses incorporation of nanoemulsions into hydrogel matrices using proper gelling agents to form a cohesive stable nanoemulgel.

Mechanisms through which nanoemulgels make drug delivery, improvement of solubility in hydrophobic drugs, penetration to target tissues, and prolongation of release profiles that could keep therapeutic drug levels up for long periods.

The article continues with further benefits that come along with the application of nanoemulgel, including presenting hydrophilic as well as lipophilic drugs, non-invasive methods of administration, enhanced drug formulations through improved stability, and improved compliance by patients because they are easy to apply and increase therapeutic outcomes.

The article discuses several therapeutic fields or application areas which include topical, transdermal, ocular, and oral drug delivery areas for which nanoemulgel can be significantly applied.