https://matjournals.net/pharmacy/index.php/TPNT/issue/feedTrends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457)2026-08-19T11:35:19+00:00Open Journal Systems<p><strong>TPN</strong> is bi-annually peer review Journal. It is with a wide scope in the arena of pharmaceutical sciences covers the topics intended to be of interest to a broad audience of pharmaceutical professionals and ideally placed to serve the needs of their readers. This Journal deals in the field of nanotechnology and cover the topics intended to be of interest to a broad audience of Nanotechnology in pharmacy. This Journal mainly focus on Nanotechnology, Nanomedicine, Pharmaceutical Technology, Pharmaceutics, Drug Processing, Nanotechnological intervention, Nanomaterial.</p>https://matjournals.net/pharmacy/index.php/TPNT/article/view/407Hydrophilic Matrix Sustained Release Tablet of Paracetamol: A Review on Formulation, Evaluation and Drug Release Characteristics2026-08-19T11:35:19+00:00Amaan Aliamaanali9537@gmail.comJyoti Saxenaamaanali9537@gmail.com<p><em>Paracetamol is a commonly used analgesic and antipyretic agent; however, its relatively short biological half-life may necessitate repeated administration to maintain the desired therapeutic effect. Sustained-release formulations have therefore attracted considerable interest as a means of extending drug action and reducing the frequency of dosing. Among the different approaches available for modified drug delivery, hydrophilic matrix tablets have been widely investigated because they are comparatively simple to formulate, economical, and suitable for conventional tablet manufacturing processes. Hydrophilic matrix systems generally contain polymers that interact with gastrointestinal fluids and form a hydrated polymeric layer around the tablet. This hydrated matrix can regulate the penetration of the dissolution medium and the movement of the drug from the dosage form. Polymers such as hydroxypropyl methylcellulose (HPMC), xanthan gum, sodium alginate, guar gum, and chitosan have been investigated for controlling drug release. The release behavior of the incorporated drug depends on several formulation variables, including polymer concentration, polymer characteristics, drug-to-polymer ratio, and the composition of the tablet matrix. The present review discusses the basic principles of sustained-release drug delivery, the role of hydrophilic polymers in matrix systems, formulation and manufacturing approaches, and important pre-compression and post-compression evaluation parameters. Particular attention is given to the preparation and evaluation of hydrophilic matrix tablets containing paracetamol and the mechanisms involved in controlling their release. The review also considers the potential advantages and formulation challenges associated with hydrophilic matrix systems. Such systems provide a practical approach for developing oral dosage forms capable of extending drug release and potentially improving dosing convenience and patient compliance.</em></p>2026-08-19T00:00:00+00:00Copyright (c) 2026 Trends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457)