Feature-Based Design Software for 3D Printing: Enhancing Accessibility to Microfluidics
Keywords:
Accessibility, Biomedical engineering, Design automation, Fabrication, Feature-based design software, 3D Printing, Microfluidics, Rapid prototypingAbstract
This paper presents a novel feature-based design software aimed at enhancing the accessibility and efficiency of 3D printing for microfluidic applications. Micro fluidics, which involves the manipulation of small volumes of fluids within micron-scale channels, has seen rapid advancements, yet the design and fabrication of microfluidic devices remain complex and require specialized knowledge. Traditional design software for 3D printing often lacks the specific tools and features needed to address the unique challenges of microfluidic system design, such as precise fluid channel geometries and integration of multiple fluidic functions. The proposed software leverages a feature-based approach, enabling users to design microfluidic systems through modular, predefined components that can be easily customized and assembled into functional devices. By offering a user-friendly interface and automating key design elements, the software significantly reduces the learning curve for users unfamiliar with microfluidic design principles. The software integrates seamlessly with 3D printing technologies, providing optimized models for fabrication. Additionally, it supports simulation tools for predicting fluid behavior within the channels, helping users to iterate on their designs more effectively. The enhanced accessibility provided by this tool opens up new possibilities for rapid prototyping, low-cost experimentation, and broader adoption of micro fluidics across various fields, including healthcare, biology, and environmental science.
References
Niculescu AG, Chircov C, Bîrcă AC, Grumezescu AM. Fabrication and applications of microfluidic devices: A review. Int. J. Mol. Sci. 2021; 22(4):2011. https://doi.org/10.3390/ijms22042011
Verma N, Prajapati P, Singh V, Pandya A. An introduction to microfluidics and their applications. Prog. Mol. Biol. Transl. Sci. 2022; 186(1):1-4. https://doi.org/10.1016/bs.pmbts.2021.07.006
Shrimal P, Jadeja G, Patel S. A review on novel methodologies for drug nanoparticle preparation: Microfluidic approach. Chem. Eng. Res. Des. 2020; 153:728-56. https://doi.org/10.1016/j.cherd.2019.11.031
Song Y, Hormes J, Kumar CSSR. Microfluidic Synthesis of Nanomaterials. Small. 2008; 4(6):698-711. https://doi.org/10.1002/smll.200701029
Pan LJ, Tu JW, Ma HT, Yang YJ, Tian ZQ, Pang DW, et al. Controllable synthesis of nanocrystals in droplet reactors. Lab on a Chip. 2018; 18(1):41-56. https://doi.org/10.1039/C7LC00800G
Tokel O, Inci F, Demirci U. Advances in Plasmonic Technologies for Point of Care Applications. Chem. Rev. 2014; 114(11):5728-52. https://doi.org/10.1021/cr4000623
Zaman MA, Padhy P, Wu M, Ren W, Jensen MA, Davis RW, et al. Controlled Transport of Individual Microparticles Using Dielectrophoresis. Langmuir. 2022;39(1):101–10. https://doi.org/10.1021/acs.langmuir.2c02235
Desagani D, Kleiman S, Zagardan T, Ben-Yoav H. 3D-Printed hydrodynamic focusing lab-on-a-chip device for impedance flow particle analysis. Chemo sensors. 2023;11(5):283. https://doi.org/10.3390/chemosensors11050283
Parolo C, Idili A, Heikenfeld J, Plaxco KW. Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices. Lab on a chip. 2023; 23(5):1339–48. https://doi.org/10.1039/D2LC00716A
Da Silva ETSG, Souto DEP, Barragan JTC, De F. Giarola J, de Moraes ACM, Kubota LT. Electrochemical Biosensors in Point-of-Care Devices: Recent Advances and Future Trends. ChemElectroChem. 2017;4(4):778–94. https://doi.org/10.1002/celc.201600758
Craighead H. Future lab-on-a-chip technologies for interrogating individual molecules. Nature. 2006; 442(7101):387-93. https://doi.org/10.1038/nature05061
Wongkaew N, Simsek M, Griesche C, Baeumner AJ. Functional Nanomaterials and Nanostructures Enhancing Electrochemical Biosensors and Lab-on-a-Chip Performances: Recent Progress, Applications, and Future Perspective. Chem. Rev. 2018;119(1):120-94. https://doi.org/10.1021/acs.chemrev.8b00172
Sengupta P, Khanra K, Chowdhury AR, Datta P. Lab-on-a-chip sensing devices for biomedical applications. Bioelectron. Med. Devices. 2019; 47-95. https://doi.org/10.1016/B978-0-08-102420-1.00004-2
Shi H, Nie K, Dong B, Long M, Xu H, Liu Z. Recent progress of microfluidic reactors for biomedical applications. Chem. Eng. J. 2019; 361:635-50. https://doi.org/10.1016/j.cej.2018.12.104
Moradi E, Jalili-Firoozinezhad S, Solati-Hashjin M. Microfluidic organ-on-a-chip models of human liver tissue. Acta. Biomater. 2020; 116:67-83 https://doi.org/10.1016/j.actbio.2020.08.041
