Lactoferrin Can Have a Role in the Treatment of Ulcerative Colitis

Abstract

Ulcerative colitis (UC) is a chronic disease featured by mucosal colon inflammation. Current treatments rely on corticosteroids, immunosuppressants, and biologics, which can have significant side effects. There is a growing interest in exploring alternative therapeutic options with fewer adverse effects. Lactoferrin, an iron-binding glycoprotein found in various body fluids, has emerged as a promising candidate.

This review explores the possible role of Lactoferrin in UC management. Lactoferrin exhibits diverse biological features, like antimicrobial, anti-inflammatory, and immunomodulatory activities. These properties make it a potential candidate for targeting the underlying mechanisms of UC, such as oxidative stress, dysregulated immune responses, and mucosal damage.