Review on Werner Syndrome
Keywords:
DNA helicase, DNA repair, Exonulcease, Genomes, Illness, Mutations, Replication, Recombination, Transcription, WRN gene, Werner SyndromeAbstract
Werner syndrome (WS), a classic segmental progeroid disorder, has several features that are associated with accelerated aging. It is caused by null mutations in the WRN gene, which codes for a RECQ family DNA helicase. The unique feature of the WRN helicase is its exonuclease domain in the N-terminal region. The WRN protein has been implicated in a number of DNA transactions over the last 10 years, including transcription, replication, recombination, and DNA repair, according to biochemical and cell biology studies. Recent discoveries of novel progeroid loci found in atypical Werner cases provide more evidence that genomic instability is a major cause of biological aging. These biological discoveries are being used to create therapeutic methods for WS and related progeroid illnesses.
