Deep Learning of Electronic Health Records: Opportunities and Challenges
Keywords:
AI in healthcare, Clinical prediction, Deep learning, Disease diagnosis, Electronic health records, Interpretability, LSTM, Privacy, TransformerAbstract
Electronic health records (EHRs) have revolutionized the healthcare sector in the sense that they have substituted the majority of the paperwork in the recording of patient records in different aspects, like diagnoses, medication, laboratory results, and clinical notes. The growing EHR information, as well as the creation of the deep learning architecture, have created unprecedented opportunities to use this information to make actionable insights regarding the prediction of diseases, their diagnosis, and individualized treatment recommendations. It is a generalized survey touching the deep learning applications sphere in EHR analysis, which is likely to have revolutionary opportunities in the form of early-stage disease diagnosis, clinical decision-making, and automatic medical records. Simultaneously, critical obstacles such as the heterogeneity of the data, privacy, the lack of interpretability, and complexities in the process of integrating are addressed. Those designs considered are state-of-the-art, including recurrent neural networks (RNNs), long short-term memory (LSTM) networks, convolutional neural networks (CNNs), transformer-based models, and graph neural networks (GNNs) applied to structured and sequential EHR data. New developments in federated learning with privacy protection, explainable artificial intelligence (XAI) with clinical interpretability and multi-modal learning approaches based on imaging, genomics, and clinical text are also highlighted. The paper would provide a comprehensive system of understanding and implementing deep learning solutions into clinical practice for healthcare organizations, researchers, and practitioners and reflect on the ethical, regulatory, and practical factors.
References
G. Hripcsak and D. J. Albers, “Next-generation phenotyping of electronic health records,” Journal of the American Medical Informatics Association, vol. 25, no. 5, pp. 540–548, May 2018.
Y. LeCun, Y. Bengio, and G. Hinton, “Deep learning,” Nature, vol. 521, no. 7553, pp. 436–444, May 2015.
A. L. Beam and I. S. Kohane, “Big Data and Machine Learning in Health Care,” JAMA, vol. 319, no. 13, pp. 1317–1318, Apr. 2018.
D. S. Char, N. H. Shah, and D. Magnus, “Implementing Machine Learning in Health Care — Addressing Ethical Challenges,” The New England Journal of Medicine, vol. 378, no. 11, pp. 981–983, Mar. 2018.
S. Hochreiter and J. Schmidhuber, “Long short-term memory,” Neural Computation, vol. 9, no. 8, pp. 1735–1780, Nov. 1997.
Y. Kim, “Convolutional neural networks for sentence classification,” in Proc. 2014 Conf. Empirical Methods in Natural Language Processing (EMNLP), Doha, Qatar, Oct. 25–29, 2014, pp. 1746–1751.
A. Vaswani et al., “Attention is all you need,” in Advances in Neural Information Processing Systems (NeurIPS), Long Beach, CA, USA, Dec. 4–9, 2017, vol. 30, pp. 5998–6008.
K. Huang, J. Altosaar, and R. Ranganath, “ClinicalBERT: Modeling clinical notes and predicting hospital readmission,” arXiv preprint, Apr. 2019.
Z. Wu, S. Pan, F. Chen, G. Long, C. Zhang, and P. S. Yu, “A comprehensive survey on graph neural networks,” IEEE Transactions on Neural Networks and Learning Systems, vol. 32, no. 1, pp. 4–24, Jan. 2021.
Z. C. Lipton, D. C. Kale, C. Elkan, and R. Wetzel, “Learning to diagnose with LSTM recurrent neural networks,” arXiv preprint, Nov. 2015.
E. Alsentzer et al., “Publicly available clinical BERT embeddings,” arXiv preprint, Apr. 2019.
W. W. Chapman, W. Bridewell, P. Hanbury, G. F. Cooper, and B. G. Buchanan, “A simple algorithm for identifying negated findings and diseases in discharge summaries,” Journal of Biomedical Informatics, vol. 34, no. 5, pp. 301–310, Oct. 2001.
A. Esteva et al., “A guide to deep learning in healthcare,” Nature Medicine, vol. 25, no. 1, pp. 24–29, Jan. 2019.
K. Bonawitz et al., “Towards federated learning at scale: System design,” in Proc. SysML Conf., Palo Alto, CA, USA, Mar. 29–31, 2019.