Journal of Pharmaceutical Quality Assurance and Quality Control

Formulation Development and Phytochemical Profiling, Finger Print (Qualitative) Analysis of Neem and Bauhinia Variegata Leaf Extract for Antidiabetic Activity

Rijwan Ahmad, Pratyush Purkayastha — Mon, 25 May 2026 00:00:00 +0000

Herbal medicines are widely recognized for their safety, efficacy, and minimal side effects compared to synthetic drugs. The present study focuses on the formulation and evaluation of herbal tablets using leaf extracts of Azadirachta indica and Bauhinia variegata, known for their antidiabetic, antimicrobial, antioxidant, and anti-inflammatory properties. Fresh leaves of both plants were collected from authenticated sources, thoroughly washed, shade dried, and pulverized into coarse powder. The powdered material was subjected to Soxhlet extraction using a suitable solvent system to obtain concentrated herbal extracts rich in active phytoconstituents. The obtained extracts were evaluated for organoleptic characteristics and incorporated into tablet formulations by direct compression technique using suitable binders, diluents, lubricants, and disintegrants. The prepared granules were assessed for various pre-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, and Hausner ratio, which indicated satisfactory flowability and compressibility necessary for tablet manufacturing. Further, the compressed tablets were evaluated for hardness, friability, weight variation, thickness, disintegration time, and uniformity of drug content according to standard pharmacopeial procedures. Phytochemical screening confirmed the presence of bioactive constituents including alkaloids, glycosides, tannins, and steroids. The results suggest that the formulated herbal tablets are stable, effective, and suitable for antidiabetic therapy.

Lauryl Salicylate (Dodecyl Salicylate): Chemistry, Synthesis, Applications, and Research Perspectives - A Review

Shivaansh Tiwari, Raj K. Prasad, Pranshu Tripathi, Arvind Kumar Srivastava — Fri, 22 May 2026 00:00:00 +0000

Lauryl salicylate, a long-chain ester mainly derived from salicylic acid and lauryl alcohol, structurally consists of an aromatic salicylate ring connected to a long alkyl chain of 12 carbon atoms, making it Amphiphilic in nature. This property helps it to bridge between oil-based and water-based environments, making it extremely important for topical and transdermal drug delivery systems. It is mainly synthesize by Fischer esterification, but evolution in recent times has introduced more efficient catalytic approaches, which are giving good output with minimum environmental effect. The main physiochemical properties which are essential for its performance are solubility, partition coefficient and lipophilicity. Lauryl salicylate shows various biological activities such as anti- inflammatory, antioxidant and antimicrobial properties, which are a result of its enzymatic system and cellular interaction. The long 12-carbon chain increases its effectiveness by improving membrane permeability; however, challenges like insufficient clinical evidence and poor water solubility are left to be studied. Future studies are more concentrated on advanced drug delivery systems and Nano technology base formulation.

Qualitative Evaluation of Some Brands of Paracetamol Suspensions Available in Retail Pharmacies in Surulere, Lagos

Ibukun Olanrewaju Adeleke, Nmesoma Queenas Uchegbu — Wed, 11 Feb 2026 00:00:00 +0000

The widespread use of paracetamol suspensions for pediatric fever and pain management in Nigeria raises critical concerns regarding the consistency and quality of different marketed brands. With a proliferation of locally manufactured and imported products, and amid persistent regulatory challenges, the potential for substandard formulations poses a significant public health risk, especially for children who are more vulnerable to therapeutic failure or toxicity. This study aimed to evaluate and compare the quality of selected brands of paracetamol suspensions available in retail pharmacies in Surulere, Lagos State, using standard methods such as assessing the organoleptic properties, pH, sedimentation rate, viscosity, drug content, microbial quality, and comparing findings with pharmacopeial specifications. Eight paracetamol suspension brands were randomly obtained from registered retail pharmacies in Surulere. Findings revealed significant brand-to-brand variation. While most brands exhibited acceptable organoleptic properties, only five out of eight met the required drug content range (90–110% of label claim). Differences in viscosity impacted redispersibility and flow characteristics, with PCM 6 exhibiting poor pourability due to excessive thickness. Microbial load for all samples was found to be within acceptable pharmacopeial limits, with no brand showing early signs of contamination after a 7-day shelf-life simulation. These results highlight quality consistencies in paracetamol suspensions marketed for pediatric use.

A Review on 3D Printing in Pharmaceuticals: Current Advances, Applications and Future Perspectives

Sandeep Kumar Sharma, Rajdeep Singh, Ishfaq Ahmad Bhat — Mon, 25 May 2026 00:00:00 +0000

Additive manufacturing or three-dimensional (3D) printing is one of the revolutionary approaches in pharmaceutical sciences, which helps address certain shortcomings associated with traditional technologies used in drug manufacturing. The latter technique allows fabricating dosage forms via an accurate layer-by-layer printing process. This way, it becomes possible to create dosage forms with complex geometries and precise drug loading and release properties. Increasing demand for customized pharmaceuticals also promotes the implementation of 3D printing, because the technique can be effectively used for making personalized formulations. A number of technologies have been actively studied in recent years to make 3D-printed dosage forms. They include fused deposition modeling, inkjet printing, stereolithography, and selective laser sintering. Using 3D printing technologies, researchers were able to develop dosage forms characterized by different drug-releasing kinetics, including immediate, sustained, and even targeted release systems. Multi-drug delivery systems in the form of polypills are now produced using 3D printing technologies. The above benefits notwithstanding, the implementation of 3D printing in the pharmaceutical sector faces certain challenges. These include regulatory aspects, quality control, manufacturing scalability, and a lack of appropriate excipients, etc. In addition, the need for standardization of the process is important. This review aims to discuss the latest trends in 3D printing technologies, as well as examine their application in the development of new pharmaceutical products and the existing challenges.

Bilastine in Ige-Mediated Allergic Disorders: Rapid Acting Second Generation Non-Sedating Antihistamine with Enhanced Safety and Therapeutic Efficacy

Thu, 21 May 2026 00:00:00 +0000

The common disorders known as allergic rhinitis and chronic urticaria can disrupt one's ability to perform daily activities and negatively affect their quality of life. The role of histamine in the development of both responses is important, and antihistamines continue to be one of the main forms of treatment for patients who suffer from these conditions. Bilastine is a newer second-generation H1 antihistamine that treats both allergic rhinitis and urticaria and has a high degree of selectivity for peripheral H1 receptors. The level of sedation produced by bilastine is very low due to the fact that it penetrates poorly into the central nervous system (CNS). In addition, bilastine has a rapid onset of action, lasting for an extended period of time, and has a better safety profile than many conventional antihistamines do. The body metabolizes the medication bilastine little to not at all and it has been shown to have a low risk for causing significant drug interactions clinically. Evidence from numerous clinical trials has shown that bilastine can reduce allergy symptoms such as sneezing, itching, runny nose, and skin rash while also providing comfort to the patient and improving their overall health. The purpose of this review is to summarize the pharmacological characteristics, mechanism of action, pharmacokinetics, therapeutic indications, safety of use, and comparative advantages of bilastine in treating allergy. Available data supports bilastine as an efficacious treatment option for rhinoconjunctivitis and chronic hives (allergic rhinitis and urticaria).