Journal of Pharmaceutical Quality Assurance and Quality Control

An Overview of RP-HPLC Method for the Determination of Valsartan in its Pure Form and Pharmaceutical Formulations

Aman Rajput — 2024-05-01

The relationship between chorioamnionitis, inflammation of fetal membranes during pregnancy, and three major pulmonary issues in premature newborns pneumonia/sepsis, respiratory distress syndrome (RDS), and bronchopulmonary dysplasia (BPD) is a subject of ongoing debate. The complexity arises from various factors before and after birth, including medical interventions, which influence the diagnosis and progression of these conditions.

Understanding the precise connections is challenging due to several reasons. Firstly, both prenatal and postnatal environments, along with medical interventions, contribute to the development of RDS, pneumonia/sepsis, and BPD. Moreover, these conditions have short-term and long-term consequences, causing them to contribute solely to chorioamnionitis difficulty. Additionally, fetal exposures are often poorly defined, and disorders like RDS and BPD may need to be more accurately identified.

Efforts to clarify these associations through large-scale multivariate studies face challenges due to the complex interplay of variables and limitations in defining fetal exposures and diagnosing pulmonary disorders. Consequently, the reliability of such studies is in question.

However, animal model research offers valuable insights into how chorioamnionitis affects fetal lung development. Through these models, researchers can understand how chorioamnionitis influences the fetal lung, potentially contributing to conditions like RDS and BPD.

A comprehensive understanding of the clinical complexity of chorioamnionitis and insights from experimental research are essential for understanding its impact on the fetal lung and improving outcomes for premature newborns. Integrating clinical observations with experimental findings can advance our understanding of the pathophysiology behind these pulmonary outcomes and aid in developing more effective prevention and management strategies.

Pharmacognostic Profiling of Natural Products for Cancer Chemoprevention and Treatment

Bharat Dhore — 2024-01-12

This research delves into the pharmacognostic profiling of natural products to explore their potential in cancer chemoprevention and treatment. With the increasing demand for effective and safer cancer therapies, the study aims to identify and characterize plant-derived compounds that exhibit promising pharmacognostic properties. The methodology involves a comprehensive review of literature, extraction, and isolation of bioactive compounds from medicinal plants renowned for their traditional use in cancer management. Various pharmacognostic parameters, including morphological, microscopic, and chemical analyses, are employed to evaluate the botanical authenticity and quality of the collected plant materials. Through these analyses, the study seeks to identify key bioactive constituents responsible for the anticancer properties of these natural products. Emphasis is placed on understanding the mechanisms underlying their chemopreventive and therapeutic effects, such as anti-inflammatory, antioxidant, and apoptotic activities. The findings of this research contribute to the growing body of knowledge on the pharmacognostic potential of natural products in cancer research. The identified compounds may serve as leads for the development of novel anticancer drugs or as complementary agents in existing cancer treatment regimens. Additionally, the study explores the synergistic interactions among different phytochemicals within the plant extracts, aiming to elucidate.

Patient Perspectives on the Integration of Pharmacy Services in Primary Care

S. Prathamesh Kumar Suresh Ithape — 2024-02-06

This research aims to investigate the attitudes and experiences of patients regarding the integration of pharmacy services within primary care settings. With the evolving landscape of healthcare, the role of pharmacists has expanded beyond traditional dispensing functions to encompass a broader scope of patient care services. This study employs a mixed-methods approach, combining surveys and in-depth interviews, to gather comprehensive insights into patients’ perceptions. The survey phase involves a diverse sample of primary care patients, exploring their awareness of integrated pharmacy services, satisfaction levels, and perceived benefits and challenges. Initial findings indicate a generally positive reception, with patients acknowledging the convenience of accessing pharmacy services alongside primary care consultations. Furthermore, respondents express interest in expanded pharmacist roles, such as medication counselling and chronic disease management. The qualitative phase involves in-depth interviews with a subset of participants to delve deeper into their experiences. Through thematic analysis, emerging themes include enhanced communication between healthcare providers, improved medication adherence, and a sense of empowerment in managing personal health. Patients appreciate the collaborative nature of integrated services, highlighting instances where pharmacist interventions positively influenced their treatment outcomes. Challenges identified through this research include limited awareness among certain demographics and concerns about privacy. The study underscores the importance of targeted education and communication strategies to address these issues and ensure widespread acceptance.