Journal of Pharmacological Research and Developments (e-ISSN: 2582-0117)

Unlocking the Power of Nature: A Comprehensive Guide to Herbal Hair Dye Formulation

Thu, 17 Jul 2025 00:00:00 +0000

Preparation of herbs such as shampoos, tablets, tonic, pasta and colours is popular with consumers. Herbal medicines are the fastest growing market for the treatment of various diseases. As knowledge of the negative results of synthetic hair colours increases, interest in the safe, environmentally friendly and healthy alternatives of hair dye is increasing. This study aims to create and evaluate a natural, plant-based hair dye utilizing organic vegetable extracts, focusing on its cosmetic and therapeutic properties. Basic elements such as Lawsonia inermis (henna), Indigofera tinctoria (indigo), and Phyllanthus emblica (amla) were selected for their ability to reduce oxidative damage. The formulation was optimized by balancing these ingredients to achieve the desired colour, strength and durability. Physicochemical characteristics of herbal synthetic dyes were assessed through measurements of pH levels, humidity, granule size, and overall solid content. In addition, the effects of resistance, maintenance and consumption of pigments for weakening were estimated to be multiple cleaning. To confirm the lack of negative reactions, it is used daily after safety verification, including dermatology stimulus tests. The results showed that the natural areas of hair dyes provide effective and durable colours with other advantages such as hair structure, hair removal and scalp food. This research outlines a secure transition to natural dyes, offering a non-toxic, plant-based alternative for hair care products, with potential for further optimization through extraction method refinement. This study demonstrates a stable and safe method for transitioning from traditional chemicals to natural alternatives. The findings suggest that natural, plant-derived dyes offer a safe and effective alternative for consumers looking for chemical-free hair products, with opportunities for further enhancement through optimized extraction techniques.

CSD in Immunocompromised Patients: Investigate the Clinical Features, Diagnosis, and Management of CSD in Patients with HIV/AIDS, Cancer, or Other Immunodeficiency

Aastha Sharma, Nancy Sharma — Thu, 17 Jul 2025 00:00:00 +0000

Cat Scratch Disease (CSD), caused by Bartonella henselae, is usually a self-limited condition in immunocompetent people. However, in immune compromised patients particularly those with HIV/AIDS, cancer, or other forms of immunodeficiency the disease can appear with unusual, severe, and widespread symptoms. CSD is frequently related with bacillary angiomatosis and peliosis hepatis in people with HIV/AIDS, both of which can be fatal. Cancer patients and transplant recipients may experience chronic fever, visceral organ involvement, or osteomyelitis. Clinical history (including cat exposure), serologic testing, Polymerase chain reaction (PCR), tissue biopsy, and imaging techniques all contribute to the diagnosis. Serologic assays and PCR are particularly useful, and Warthin-Starry stains may aid in histopathological identification. Prolonged antibiotic treatment is part of management; for severe instances, rifampin is frequently used in conjunction with macrolides or doxycycline. Longer treatment periods are usually needed for immunocompromised patients, and relapse is not unusual if immune reconstitution is not accomplished. In this high-risk group, early identification and customized treatment are crucial to enhancing results and avoiding problems.

Effectiveness of Ocimum sanctum Drugs and Drops: A Botanical and Pharmacological Perspective

Vanshika Sharma, Preeti Sharma, Ujjwal Vats — Fri, 18 Jul 2025 00:00:00 +0000

Ocimum sanctum (O. sanctum) commonly known as Tulsi or Holy Basil, is a revered medicinal plant in Ayurveda, valued for its antimicrobial, anti-inflammatory, antioxidant, and immunodulatory properties. This paper evaluates the effectiveness of commercially available Ocimum sanctum based drugs and drops, focusing on their botanical characteristics, phytochemical composition, and therapeutic efficacy. Microbiological screening using the well diffusion method revealed significant antimicrobial activity of Tulsi extracts and formulations.

Unraveling Neurodegeneration: Pathogenesis, Prevalence and Prospect for Treatment

Tejaswini, Omkar Deavde, Vivekumar Redasani, Kunal N. Gaikwad — Sat, 02 Aug 2025 00:00:00 +0000

Neurodegenerative disorders are a collection of conditions marked by the progressive decline of neurons, which leads to cognitive deterioration and reduced functional abilities. Alzheimer’s disease (AD), the leading cause of dementia, is responsible for approximately 60–80% of all dementia cases. Its hallmarks include the buildup of amyloid-β plaques and neurofibrillary tangles composed of tau protein, which disrupt neural signaling and trigger synaptic degeneration and neuronal death. As a result, patients experience brain shrinkage, particularly within the hippocampus and cerebral cortex. Aside from AD, the category of neurodegenerative diseases also encompasses conditions like Parkinson’s disease, multiple sclerosis (MS), and various other forms of dementia. Each of these illnesses has unique pathological characteristics and clinical presentations. Parkinson’s, for example, primarily involves the degeneration of dopamine-producing neurons in the substantia nigra, leading to tremors, muscle stiffness, and related motor disturbances.

In contrast, MS is an autoimmune condition characterized by the immune system attacking the myelin sheath, causing impaired nerve transmission and neurological deficits. Dementia, more broadly, refers to cognitive disorders of varying etiology, of which Alzheimer’s is the most common. This review aims to summarize the current understanding of neurodegenerative disorders, emphasizing Alzheimer’s disease. We will examine its definition, the mechanisms underlying its pathology, and available treatment approaches. Gaining insight into these areas is vital for advancing therapies and enhancing the lives of those living with these challenging conditions.