Organogels as Topical Drug Delivery System

Abstract

A three-dimensional network of interwoven, self-assembling gelator fibers that immobilize an organic liquid phase constitutes organogels, which is a semi-solid structures. These systems have the appearance and rheological behaviour of solids, even though their composition is primarily liquid. Only in the last several decades has there been a notable increase in research interest in organogels, which has led to a better knowledge of their structure and function. However, many elements of organogel systems remain obscure, particularly the specific molecular mechanisms and circumstances that enable and govern gelation. Despite these knowledge gaps, the quick growth of research has resulted in the creation and use of numerous organogel systems in a variety of sectors. Their unique features, including thermodynamic stability, biocompatibility, and ease of synthesis, have made them particularly attractive as delivery matrices for bioactive chemicals. Because of their structural integrity and stability, organogels have been investigated for their potential in regulated and prolonged drug release as well as in applications relating to food, medicine, and cosmetics. The goal of this work is to illustrate the basic properties of organogels, with a particular emphasis on the many kinds of organogelators that create their unique networks. It also looks at how versatile organogels are as carriers in regulated delivery systems. By knowing their composition, formation mechanisms, and functional benefits, organogels can be better used in building effective and creative delivery platforms for a wide range of therapeutic and industrial uses.