A New Approach to Naso Pulmonary Drug Delivery System

Abstract

Drugs can be administered by nasal administration, which involves inhaling them through the nose. Naso-pulmonary medication delivery is a cutting-edge and exciting method for administering therapeutic drugs locally as well as systemically. Among the many advantages of the nasal route are its large surface area, strong vascularization. It ensures rapid onset and avoids the drug’s early metabolism in the liver. It allows effective delivery of drugs, proteins, and peptides that cannot remain stable in the digestive system. Pulmonary delivery provides individualized treatment for respiratory conditions such as asthma, COPD, and pulmonary infections by increasing medication efficacy and lowering systemic side effects. Numerous factors, such as formulation properties, pH, mucociliary clearance, lipophilicity, and molecular size, affect drug absorption through the nasal and pulmonary routes. The various dosage forms that allow for flexible and effective administration include nasal drops, sprays, gels, and powders. Thanks to advancements in formulation science and nanotechnology, naso-pulmonary medication delivery is a practical, non-invasive, and efficient way to treat respiratory and systemic disorders.