Solid Dispersion Technology: A Review of Recent Advances and Applications
Keywords:
Bioavailability enhancement, Drug solubility, Hot-melt extrusion, Polymer carriers, Solid dispersionAbstract
Solid dispersion technology is a well-established and widely used method for enhancing the solubility and bioavailability of poorly water-soluble drugs. The technique involves the dispersion of the drug in an inert matrix or carrier material, thereby improving the dissolution rate, which is often a limitation for many pharmacologically active compounds. Over the past few years, advances in solid dispersion systems have made them a promising approach for drug development, especially for the formulation of oral dosage forms. Various methods, including solvent evaporation, fusion, and hot-melt extrusion, are employed to prepare solid dispersions, each with its own advantages and challenges. Additionally, a wide range of carriers, such as polymers, surfactants, and lipids, have been explored to optimize the performance of solid dispersions. Recent research highlights the importance of understanding the physical characteristics and stability of these systems to ensure their efficacy in clinical applications. Despite their significant potential, challenges related to stability, scale-up production, and regulatory considerations remain. This review article aims to present a comprehensive analysis of the recent advancements in solid dispersion technology, focusing on its formulation strategies, applications, and future perspectives. Moreover, it will also examine the potential for overcoming the challenges associated with these systems to enhance their commercialization prospects in the pharmaceutical industry.
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